Fluorescent nitric oxide detection using cobalt substituted myoglobin
نویسندگان
چکیده
منابع مشابه
Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation.
BACKGROUND Hypoxic vasodilation is a physiological response to low oxygen tension that increases blood supply to match metabolic demands. Although this response has been characterized for >100 years, the underlying hypoxic sensing and effector signaling mechanisms remain uncertain. We have shown that deoxygenated myoglobin in the heart can reduce nitrite to nitric oxide (NO·) and thereby contri...
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Nitric oxide (NO) is important physiologically as a gaseous messenger in the central nervous system;1 its level is also associated with several disease states.2 The concentration of NO in these cases is in the nanomolar range; therefore accurate and direct detection of NO at these levels is important. NO is also a decomposition product of several explosives3 so detection of trace amounts of exp...
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ژورنال
عنوان ژورنال: RSC Advances
سال: 2014
ISSN: 2046-2069
DOI: 10.1039/c3ra47658h